Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder

This study is testing a personalized, non-invasive brain stimulation technique (like targeted magnetic or electrical pulses to the brain) as a treatment for major depressive disorder (MDD) — severe depression — in people who have not responded well enough to medications. **You may be eligible if...** - You are between 18 and 70 years old - You have a confirmed diagnosis of major depressive disorder (unipolar, non-psychotic) - Your depression symptoms are at least moderate in severity (HDRS-17 score of 14 or above) - You have low suicide risk (no active suicidal thoughts in the past month, no attempts in the past 2 years) - You are willing to follow all study procedures **You may NOT be eligible if...** - You have a severe alcohol use disorder in the past year - You have a moderate-to-severe substance use disorder (other than tobacco) in the past year - You have a psychotic illness or bipolar disorder - You have medical conditions that make brain stimulation unsafe (such as certain metal implants in the head) Talk to your doctor to see if this trial is right for you.