Risk Factors for Inadequate Bowel Preparation Before Colonoscopy
Identification of Risk Factors for Inadequate Bowel Preparation Before Colonoscopy and Construction of a Predictive Model: a Nationwide Multicenter Prospective Study
Changhai Hospital
10,000 participants
Feb 21, 2025
OBSERVATIONAL
Conditions
Summary
The primary objectives of this study are twofold: Firstly, to investigate the current status of bowel preparation protocols and their quality across hospitals at various levels in China, particularly following the release of the updated 2023 bowel preparation guidelines. This aims to standardize and optimize bowel preparation protocols nationwide. Secondly, to identify and analyze risk factors contributing to suboptimal bowel preparation quality in patients undergoing colonoscopy. The study will examine the correlation between these factors and bowel preparation scores, establish a risk prediction model for preparation failure, and provide a theoretical foundation for developing personalized bowel preparation regimens tailored to individual patient characteristics.
Eligibility
Inclusion Criteria2
- Patients aged >18 years, regardless of gender, scheduled for colonoscopy
- Written informed consent has been obtained
Exclusion Criteria11
- History of acute myocardial infarction (within 6 months), severe cardiac/hepatic/renal insufficiency, or psychiatric disorders
- Current use of anticoagulants (e.g., aspirin, warfarin) or presence of coagulation disorders
- Pregnancy or lactation;
- History of inflammatory bowel disease or acute intestinal infection within the past 2 weeks;
- History of colorectal cancer, familial adenomatous polyposis (FAP), or Peutz-Jeghers syndrome;
- History of intestinal obstruction, perforation, stricture, or other conditions precluding completion of colonoscopy;
- Non-compliance with bowel preparation protocols (e.g., ingestion of <80% of prescribed polyethylene glycol (PEG) electrolyte solution);
- Severe hearing impairment, cognitive dysfunction, or inability to cooperate with the study;
- Prior enrollment in this study with a repeat colonoscopy appointment;
- Current participation in other clinical trials or participation in any trial within the preceding 60 days;
- Refusal to provide written informed consent.
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Interventions
Observed parameters include BMI, history of abdominal surgery, history of diabetes, history of diarrhea and constipation, stool characteristics, and specific bowel preparation protocols.
Locations(1)
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NCT06878378