RecruitingPhase 2Phase 3NCT06879379

KPD Consolidation After ASCT in NDMM Patients

A Randomized, Multicenter Study Comparing Post-Transplant KPD Regimen Consolidation With No Consolidation in Newly Diagnosed Multiple Myeloma (NDMM) Transplant-eligible Patients


Sponsor

Peking University People's Hospital

Enrollment

202 participants

Start Date

Mar 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to evaluate the efficacy and safety of post-transplant consolidation therapy with the KPD regimen (carfilzomib, pomalidomide, and dexamethasone) versus no consolidation, followed by maintenance therapy, in patients with transplant-eligible newly diagnosed multiple myeloma (TE-NDMM). The primary goal is to compare minimal residual disease (MRD) negativity rates and overall treatment outcomes between the two groups.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a combination therapy called KPD (carfilzomib, pomalidomide, and dexamethasone) as consolidation treatment for newly diagnosed multiple myeloma patients who have recently completed a stem cell transplant. Consolidation means giving extra treatment after transplant to deepen the response and keep the cancer away longer. **You may be eligible if:** - You are 18 or older with newly diagnosed multiple myeloma - You were eligible for and received a stem cell transplant (ASCT) - You received a standard induction regimen of 3 or 4 drugs before your transplant - Your ECOG score is less than 2 (meaning you are able to care for yourself) - Your heart, liver, and kidney function are adequate **You may NOT be eligible if:** - Your myeloma was previously treated (not newly diagnosed) - You did not receive a stem cell transplant - Your organ function is significantly impaired - You have a serious active infection or another cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGKPD (carfilzomib, pomalidomide, and dexamethasone) consolidation

After post-transplant randomization, patients will receive either KPD (carfilzomib, pomalidomide, and dexamethasone) consolidation then maintenance or no consolidation and maintenance.


Locations(3)

Peking University People's Hospital

Beijing, Beijing Municipality, China

Fuxing Hospital affiliated to Capital Medical University

Beijing, Beijing Municipality, China

Shanghai Changzheng Hospital

Shanghai, Shanghai Municipality, China

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NCT06879379


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