Immunomodulation During Pregnancy
Immunomodulation During Pregnancy Through Low-Dose Aspirin: a Hypothetical Mechanism for the Prevention of Preeclampsia?
Unidade Local de Saúde de Coimbra, EPE
30 participants
Feb 1, 2024
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied. The main question it aims to answer is: evaluate the effect of LDA on the modulation of innate immunity cells (NK cells, monocytes, γδ T cells) and/or acquired immunity (B and T lymphocytes, Treg cells, Th cells). Participants already taking intervention A as part of their regular medical care for RA will answer online survey questions about their joint pain for 5 years.
Eligibility
Inclusion Criteria3
- Patients attending prenatal consultations at the Obstetrics Service A of CHUC, with the first consultation occurring before 14 weeks of gestation
- Gestational age determined by first-trimester ultrasound
- Study group: Women classified as high risk for PE according to clinical/historical criteria and the Fetal Medicine Foundation algorithm. LDA-naïve.
Exclusion Criteria4
- Autoimmune diseases
- Prior use of LDA or other immunomodulatory medication before potential recruitment
- History of spontaneous miscarriages and/or medical termination of pregnancy
- Fetal malformation
Interested in this trial?
Get notified about updates and connect with the research team.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06882850