RecruitingNot ApplicableNCT06886451

Vomiting Prevention in Children With Cancer

Prevention of Vomiting in Pediatric Oncology Inpatients Using Machine Learning


Sponsor

The Hospital for Sick Children

Enrollment

1,332 participants

Start Date

Mar 18, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this single arm trial is to learn if a machine learning (ML) model predicting the risk of vomiting within the next 96 hours will impact vomiting outcomes in inpatient cancer pediatric patients. The main questions it aims to answer are whether an ML model predicting the risk of vomiting within the next 96 hours will: Primary 1\. Reduce the proportion with any vomiting within the 96-hour window Secondary 1. Reduce the number of vomiting episodes 2. Increase the proportion receiving care pathway-consistent care 3. Impact on number of administrations and costs of antiemetic medications Newly admitted participants will have a ML model predict the risk of vomiting within the next 96 hours according to their medical admission information. The prediction will be made at 8:30 AM following admission. Pharmacists will be charged with bringing information about patients' vomiting risk to the attention of the medical team and implementing interventions.


Eligibility

Inclusion Criteria1

  • All pediatric patients admitted to the oncology service at SickKids

Exclusion Criteria1

  • Pediatric patients admitted to the oncology service at SickKids that are discharged prior to prediction time

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Interventions

OTHERML-based intervention

For each patient, a ML model will predict the risk of vomiting within the next 96 hours. Patients will then receive care pathway-consistent interventions based on the ML model predictions.


Locations(1)

The Hospital for Sick Children

Toronto, Ontario, Canada

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NCT06886451


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