Timing of Anticoagulant Administration During Radial Access Percutaneous Coronary Intervention: the HERA-PCI Study (Heparin Early for Radial Access Percutaneous Coronary Intervention)
University Hospital, Strasbourg, France
550 participants
Jun 5, 2025
INTERVENTIONAL
Conditions
Summary
While the reduced hemorrhagic risk of radial access for percutaneous coronary intervention compared to femoral access is well-established, its main complication remains radial artery occlusion, which can occur in up to 30% of patients. Anticoagulation is the primary preventive measure recommended in clinical practice to reduce the risk of this complication, typically involving heparin injection during the procedure in most centers. However, data on the effect of the timing of heparin injection are limited. The investigators hypothesize that injection of heparin before sheath insertion may reduce the rate of radial artery occlusion compared with injection after sheath insertion.
Eligibility
Inclusion Criteria4
- Patients having 18 years old or older, regardless of gender, undergoing percutaneous radial coronary intervention
- Subject affiliated to a social protection health insurance
- Subject able to understand the objectives and risks of the research and to provide dated and signed consent
- Subject who has been informed of the results of the preliminary medical examination
Exclusion Criteria9
- Contraindication to the use of heparin (history of heparin-induced thrombocytopenia)
- Very high bleeding risk defined by recent bleeding (\<6 months) of type 3 of the BARC classification
- Subject in an exclusion period (determined by a previous or ongoing study)
- Inability to give the subject enlightened information (subject in an emergency situation, difficulties in understanding the subject, etc.)
- Subject under safeguard of justice
- Subject under guardianship or curatorship
- Pregnancy
- Breastfeeding
- Patient on anticoagulant treatment: anti-vitamin K, direct oral anticoagulants (DOACs).
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Administration of heparin after sheath insertion
Administration of heparin prior to sheath insertion
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06890312