RecruitingNCT06896370

An Observational Study for Gastric Cancer in Carriers of High Risk Helicobacter Pylori

Risk of Gastric Cancer in High-risk Carriers of Helicobacter Pylori: an Observational Cohort Study


Sponsor

Fudan University

Enrollment

3,000 participants

Start Date

Jul 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This study is intended to be a prospective observational cohort study. The incidence of gastric cancer and progression of gastric precancerous lesions will be compared between groups through prospective follow-up of a population with baseline negative gastric endoscopy, harboring high-risk Hp SNP subtypes and non-high-risk subtypes.


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is following people who carry a high-risk strain of Helicobacter pylori — a common stomach bacteria — to monitor whether they develop stomach cancer over time. H. pylori infection is the leading cause of stomach cancer worldwide, and certain strains are more dangerous than others. Researchers want to understand the natural progression from H. pylori infection to cancer, and identify who is at highest risk so that prevention strategies can be improved. **You may be eligible if...** - You are 40 years or older - You are willing to attend baseline and follow-up check-up appointments - You are able to provide informed consent **You may NOT be eligible if...** - You have already been diagnosed with stomach cancer or another digestive tract cancer - You have serious underlying health conditions (such as severe heart, lung, or kidney failure) that make follow-up unsafe - You are unable or unwilling to attend required follow-up visits - You have a condition that would make endoscopy (stomach camera examination) unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERobservational study

By prospectively following a population of asymptomatic carriers carrying high-risk Hp SNP subtypes and non-high-risk subtypes, the incidence of gastric cancer and progression of gastric precancerous lesions were compared between the groups.


Locations(1)

People's Hospital of Tongling City

Tongling, China

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NCT06896370


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