Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines
Evaluating the Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines in the Emergency Department
Wake Forest University Health Sciences
100 participants
Dec 16, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.
Eligibility
Inclusion Criteria4
- Age ≥ 18 years or older
- Able to provide informed consent
- English speaking
- Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, who experience headaches with typical migraine features (e.g at least 2-3 of the following: recurrent, unilateral, pounding or throbbing in nature, associated with nausea), AND with a clinical exclusion of migraine mimics
Exclusion Criteria6
- Pregnancy defined as a positive urine HCG
- Allergy or sensitivity to study drug
- Stated history of renal insufficiency
- Documented history of myasthenia gravis
- Consumption of study drug within 48 hours prior to enrollment
- Previously enrolled in this trial during a different patient encounter
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Interventions
Prochlorperazine 10 mg administered as an intravenous push over 2 minutes followed by magnesium 2 g administered as an intravenous bolus over a period of 20 minutes
Prochlorperazine 10 mg administered as an intravenous push over 2 minutes followed by placebo (normal saline)
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06904287