RecruitingPhase 2NCT06904482

Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood


Sponsor

Case Comprehensive Cancer Center

Enrollment

36 participants

Start Date

Aug 13, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to see if see if adding the specific combination of donors can result in acceptable levels of survival without evidence of disease.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a stem cell transplant approach that combines a partially matched (haploidentical) donor graft with donated umbilical cord blood to treat high-risk blood cancers — aiming to reduce the risk of transplant rejection and complications. **You may be eligible if...** - You have been diagnosed with a high-risk blood cancer such as AML (acute myeloid leukemia), ALL (acute lymphoblastic leukemia), MDS, CML, NHL, or Hodgkin lymphoma - Your cancer is in remission or at a specific disease stage required by the study - You do not have a fully matched sibling donor available - Your overall health is sufficient to undergo a stem cell transplant **You may NOT be eligible if...** - Your cancer is active and not in remission - You have serious organ damage or infections - You have a fully matched sibling donor available (in most cases) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALHaplo-Identical / Cord Blood Transplant

Cord Blood Unit Selection Cord Blood Unit Selection should be consistent with published guidelines5 with the understanding that the goal cell dose is 1x105 CD34 cells/kg in this protocol. ABO matching and donor specific antibodies should be taken into account in the selection of the CB unit. Haplo-Donor Selection Haplo-identical siblings and younger male donors are preferred. ABO matching, CMV compatibility, and donor specific antibodies should be taken into account in the selection of the donor.


Locations(1)

Case Comprehensive Cancer Center, University Hospitals Cleveland Medical Center Seidman Cancer Center

Cleveland, Ohio, United States

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NCT06904482


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