Using 4D Urinary Proteomics to Predict and Evaluate Treatment Response in Colorectal Cancer

This study is looking at whether proteins found in urine can predict how well colorectal cancer will respond to chemotherapy and other treatments before surgery — which could help doctors personalize treatment plans. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with locally advanced colorectal cancer (cancer that has grown into nearby tissue or lymph nodes) confirmed by biopsy - Your cancer has not spread to distant organs - You are planned to receive chemotherapy or other treatment before surgery (neoadjuvant therapy) - You have not had any prior targeted therapy or immunotherapy - You are willing to provide urine samples at specific timepoints **You may NOT be eligible if...** - You have a history of other cancers - You have serious kidney, liver, heart, or metabolic problems that could affect urine protein levels - Your cancer has already spread to other organs Talk to your doctor to see if this trial is right for you.