SIRT Versus cTACE for Unresectable HCC (CHANCE2506)

This study is comparing two procedures used to treat liver cancer (hepatocellular carcinoma) that cannot be surgically removed: SIRT (selective internal radiation therapy, using radioactive beads delivered to the tumor via a catheter) versus cTACE (conventional chemoembolization, which blocks blood supply to the tumor while delivering chemotherapy directly), to see which one is more effective. **You may be eligible if...** - You have confirmed liver cancer (hepatocellular carcinoma) that cannot be or you have declined surgery - Your cancer has not spread outside the liver - The tumor takes up less than 50% of your liver - You are in reasonable health (ECOG 0–1) and your liver, kidney, and blood counts are within acceptable levels - Your expected survival is at least 3 months **You may NOT be eligible if...** - Your cancer has spread outside the liver - Your liver function is too impaired - You have certain vascular conditions that would make the procedure unsafe Talk to your doctor to see if this trial is right for you.