RecruitingNot ApplicableNCT06909890

A Study of Chios Mastic Water in Dyspepsia

The Effectiveness of a Natural Aqueous Extract of Chios Mastic in the Management of Dyspepsia: the MASTIQUA-D Randomized Controlled Clinical Trial

Sponsor

Harokopio University

Enrollment

60 participants

Start Date

Jul 10, 2025

Study Type

INTERVENTIONAL

Conditions

Dyspepsia

Summary

Chios mastic is a natural product with strong antimicrobial, anti-inflammatory and antioxidant properties, and well-established benefits for dyspeptic disorders. The aim of the present study is to investigate the effectiveness of a natural aqueous extract of Chios mastic (mastic water), a by-product of Chios mastic processing, in the management of dyspepsia. This will be a 3-month randomized double-blind controlled clinical trial in adults with dyspepsia. Participants will be blindly randomized to an intervention group, which will receive 600 mL/d of a carbonated beverage enriched with Chios mastic water (0.2%), or a control group, which will receive 600 mL/d of an identical placebo beverage with no active ingredients. Participants will be evaluated in terms of anthropometric indices, lifestyle habits, severity of dyspepsia-related gastrointestinal symptoms, quality of life, as well as biochemical markers, both pre- and post-intervention.

Eligibility

Min Age: 30 YearsMax Age: 60 Years

Inclusion Criteria3

Age 30-60 years old.
Body mass index of 20-35 kg/m2.
Presence of dyspepsia.

Exclusion Criteria7

Presence of chronic diseases (e.g. diabetes mellitus, cancer, cardiovascular, hepatic, renal, respiratory, chronic inflammatory and psychiatric diseases).
Presence of other chronic gastrointestinal diseases (e.g. gastroesophageal reflux, inflammatory bowel disease and celiac disease).
Use of immunosuppressants, anti-inflammatories, antibiotics and corticosteroids.
Use of dietary supplements or other products with Chios mastic.
Excessive alcohol consumption (>210 g and >140 g of ethanol per week for men and women, respectively).
Currently on a weight-loss diet or recent (within 6 months) significant change in lifestyle habits.
Pregnancy or breast feeding (for women)

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Interventions

BEHAVIORALChios mastic beverage

Participants of this intervention arm will be provided with a sparkling beverage enriched with the natural mastic aqueous extract (0.2%), a by-product of Chios mastic processing, and will be asked to consume it daily (3 bottles of 200 mL each) for 3 months. Participants will also be instructed to maintain their usual lifestyle practices and medical treatment stable.

BEHAVIORALPlacebo beverage

Participants of this intervention arm will be provided with a placebo sparkling beverage (same organoleptic characteristics with experimental beverage but no active ingredients) and will be asked to consume it daily (3 bottles of 200 mL each) for 3 months. Participants will also be instructed to maintain their usual lifestyle practices and medical treatment stable.