Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients
University Hospital, Limoges
556 participants
Sep 20, 2025
INTERVENTIONAL
Conditions
Summary
Despite early treatment, the deterioration and mortality of sepsis patients remains high. A possible explanation could be persistent tissue hypoperfusion, or undetected in the early phase despite the normalization of macro-hemodynamic parameters. This interventional study evaluates the impact of measuring microcirculation parameters by nurses on patient prognosis through early initiation of vascular filling.
Eligibility
Inclusion Criteria4
- Age ≥ 18 years
- Admitted to the Emergency Department for suspected Sepsis for less than 6 hours according to international Sepsis-3 definitions (high probability of infection defined by a fever greater than or equal tol to 38.3°C with a suspected infectious source + Score NEWS 2 greater than or equal to 2)
- Affiliated to a social security system
- Having agreed to participate in this study
Exclusion Criteria5
- Patient with arterial hypotension (SBP ≤ 100 mmHg) on admission
- Patient having already received a 500mL filling test over 30 minutes
- Patients moribund according to the investigator
- Pregnancy or breastfeeding
- Patient under guardianship, curatorship or safeguard of justice
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Interventions
in addition to the classic hemodynamic parameters measured in all patients, a measurement of the peripheral perfusion index (from 1 sec to 10 sec) and marbling assessment (scale from 0 to 5) will be performed
Locations(6)
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NCT06910891