RecruitingNCT06911658

Infectious Complications After Esophagectomy

Infectious Complications, Associated Factors, and Prognosis After Esophagectomy for Cancer: A French, Multicenter, Retrospective Study - CIFO-study


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

350 participants

Start Date

Aug 27, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Infectious complications represent the most common postoperative adverse events following esophagectomy for cancer, such as pneumonia (15% of cases). These complications increase immediate risks, lengthen hospital stays, and worsen patient quality of life. The population includes patients admitted to intensive care after esophagectomy for cancer between January 1, 2017, and December 31, 2024. The study focuses on this population due to the increasing incidence of esophageal cancer, the increased use of surgery for these indications, and the importance of postoperative infections in these complex procedures, despite their understudied nature in the current literature. Identifying modifiable risk factors could lead to corrective measures and thus improve the prognosis of postoperative patients. The research focuses primarily on the incidence, types, factors, and prognosis associated with the occurrence of infections after esophagectomy for cancer. It also includes an analysis of the pathogens involved, their resistance profiles, and the antibiotic therapies used in first-line probabilistic treatment.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Patients over 18 years of age
  • Underwent esophagectomy for cancer between January 1, 2017, and December 31, 2024
  • Scheduled admission to intensive care for postoperative monitoring

Exclusion Criteria1

  • Opposition to the use of data

Locations(2)

Hôpital Saint-Louis - APHP

Paris, France

Saint Louis Hospital

Paris, France

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NCT06911658


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