Hypoxia, Appetite, and Energy Intake in Young Female Adults
Appetite and Energy Intake in Young Female Adults During and After Simulated High-Altitude
University of Ottawa
10 participants
Nov 13, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to investigate the effects of acute passive continuous hypoxemia (simulated high-altitude at rest) on appetite and energy intake in healthy young female adults. The main questions it aims to answer are: * Does six hours of simulated high-altitude (5000 meters) reduce scores of subjective appetite and energy intake? * Do changes in appetite and energy intake persist in the hours following the end of hypoxic exposure? Researchers will compare the effects of simulated high-altitude to a control normoxia (sea-level) condition to see if exposure to low oxygen levels independently affect appetite and energy intake. Participants will: * Visit the laboratory for a preliminary screening session to assess eligibility. * Undergo two randomized, single-blind, experimental sessions consisting of six hours of passive exposure to normoxia or hypoxia in a climate-controlled chamber. * Consume foods provided from a curated list, served in ad libitum quantities, after leaving the laboratory to assess post-exposure energy intake.
Eligibility
Inclusion Criteria2
- English or French speaking
- Ability to provide informed consent
Exclusion Criteria7
- History or evidence of chronic disease
- Current use of hypolipemic medication
- Current use of hormonal contraceptives
- Current use of antidepressants
- Current use of anticoagulants
- Ongoing smoking status
- Experiencing pregnancy, puerperium, or irregular menstrual cycles
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Interventions
Participants will undergo a 6-hour passive exposure to normoxia in a climate-controlled environmental chamber maintained at 22°C with 30% relative humidity. They will remain in a fasted state throughout the exposure period.
Participants will undergo a 6-hour passive exposure to a simulated altitude of 5000 meters above sea-level in a climate-controlled environmental chamber maintained at 22°C with 30% relative humidity. They will remain in a fasted state throughout the exposure period.
Locations(1)
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NCT06912230