RecruitingPhase 1NCT06914037

A Clinical Study of CHT101 in CD70-Positive Relapsed or Refractory Hematological Malignancies

A Phase 1, Open-Label, Single-Arm Study of the Safety, Pharmacokinetics and Efficacy of CHT101 in Subjects With Relapsed or Refractory T or B Cell Hematological Malignancies


Sponsor

Tianjin Medical University Cancer Institute and Hospital

Enrollment

24 participants

Start Date

Mar 31, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Evaluate the Safety, Pharmacokinetics and Efficacy of CHT101 in Subjects With Relapsed or Refractory T or B Cell Hematological Malignancies


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new antibody-drug treatment called CHT101 that targets a protein called CD70 on cancer cells, in people with certain relapsed or refractory blood cancers — including T-cell lymphoma, B-cell lymphoma, and chronic lymphocytic leukemia. **You may be eligible if...** - You are between 18 and 70 years old - Your tumor tissue has tested positive for CD70 by laboratory testing - You have a specific type of blood cancer (T-cell lymphoma, B-cell lymphoma, or CLL) that has come back or stopped responding to standard treatments - You have received the minimum number of prior treatment regimens required for your cancer type - You are in generally good physical condition **You may NOT be eligible if...** - Cancer has spread to your brain or spinal cord - You have had an organ transplant - You have previously received CAR-T therapy or CD70-targeting drugs - You have an active infection requiring treatment - You have an active autoimmune disease requiring immunosuppressive medication Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCHT101

CD70 UCAR-T


Locations(1)

Tianjin Medical University Cancer Institute & Hospital

Tianjin, Tianjin Municipality, China

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NCT06914037


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