Development of a Cough Control Questionnaire (CCQ)
The Development and Validation of a Cough Control Questionnaire
King's College Hospital NHS Trust
100 participants
Apr 1, 2025
OBSERVATIONAL
Conditions
Summary
Chronic cough (\>8 weeks in duration) affects 5-12% of the global population, and is associated with considerable health status impairment and comorbidities. Currently, there are validated severity and impact outcome measures whilst objective measures with cough frequency monitoring is not available in routine clinical practice. Unlike other chronic respiratory diseases, namely asthma, there are no validated dedicated tools to assess the control of cough as a disease. This study aims to develop a validated patient-focused tool to assess the control of cough, which may be useful to evaluate the benefit and value of treatments in both clinical and research settings.
Eligibility
Inclusion Criteria1
- Adult patients aged 18 and over with acute and chronic cough (including refractory chronic cough and unexplained chronic cough) and able to read and write in English. A smaller number (n =20) of healthy volunteers will also be included with no evidence of significant respiratory disease.
Exclusion Criteria1
- Current smokers (or smoking within the last 12 months), respiratory tract infection within the last 4 weeks, use of angiotensin converting enzyme inhibitors (ACEi), and pregnancy
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Interventions
Completion of new questionnaire in addition to other patient reported outcome measures that measure cough severity and cough-related quality of life.
Semi-structured focus group interviews for patients with refractory chronic cough
Cough monitoring and cough sensitivity testing.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06918756