RecruitingPhase 3NCT06919614

STI Testing to Enhance PrEP Use in Pregnancy

Improving PrEP Outcomes Among Pregnant Women in Botswana With an Integrated STI Testing and PrEP Delivery Model

Sponsor

Botswana Harvard AIDS Institute Partnership

Enrollment

600 participants

Start Date

Jun 18, 2025

Study Type

INTERVENTIONAL

Conditions

Pregnancy Sexually Transmitted Infections (STIs)PrEP Adherence

Summary

The investigators are conducting a study in Botswana to see if offering STI testing along with expanded HIV prevention options (PrEP) helps more pregnant women start and continue using PrEP during and after pregnancy. Pregnant women (n=600) seeking antenatal care in Botswana will be enrolled and randomly assigned to receive the standard of care (standard STI assessment with no STI testing) versus STI testing for Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis during pregnancy and postpartum. The investigators' hypothesis is that providing STI testing alongside PrEP offer will encourage more women to start and continue using PrEP.

Eligibility

Sex: FEMALE

Plain Language Summary

Simplified for easier understanding

This study is testing whether routine STI (sexually transmitted infection) testing during pregnancy can encourage more pregnant women to use PrEP — a daily medication that prevents HIV infection. The goal is to protect both mother and baby from HIV during and after pregnancy. **You may be eligible if...** - You are pregnant and seeking prenatal care - You identify as a cisgender woman - You do not have HIV - You are not currently taking PrEP - You plan to stay in your current city through 9 months after delivery - You plan to receive prenatal and postnatal care locally **You may NOT be eligible if...** - You are not pregnant - You are male - You are already living with HIV - You are already taking PrEP - You plan to move away before 9 months after delivery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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