RecruitingPhase 2NCT06919926

Clinical Trial Evaluating the Efficacy of AGB101 for Reducing Hippocampal Overactivity in Older Adults

A Randomized, Within-subject, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of AGB101 (Low-dose Levetiracetam, 220 mg, Extended Release Tablet) for the Treatment of Hippocampal Overactivity in the Elderly


Sponsor

Johns Hopkins University

Enrollment

60 participants

Start Date

Apr 17, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This randomized, crossover, placebo controlled clinical study will assess the efficacy and safety of a slow release form of levetiracetam (AGB101) in the treatment of cognitively normal adults by measuring change in several imaging measures over the course of a two week treatment period.


Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called AGB101 and a drug called Placebo for people with dementia and hippocampal overactivity. The study is currently recruiting participants at 1 location. People eligible for this study include aged 50 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAGB101

low-dose levetiracetam, 220 mg, extended release tablet

DRUGPlacebo

placebo capsule


Locations(1)

Johns Hopkins University School of Medicine

Baltimore, Maryland, United States

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NCT06919926


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