Navigation Interventions to Improve Cascade Genetic Testing Among Relatives of Patients With Hereditary Cancer Syndromes
Testing Effectiveness of Navigation Interventions to Increase Uptake of Cascade Genetic Testing Among Relatives of Individuals Diagnosed With Hereditary Cancer Syndromes
University of Michigan Rogel Cancer Center
500 participants
Sep 23, 2025
INTERVENTIONAL
Conditions
Summary
This clinical trial tests whether various web-based tools can help improve communication about hereditary cancer risk in families and decrease barriers to genetic testing for relatives of patients with hereditary cancer syndromes. Between 5% and 10% of all cancers are caused by genetic changes that are hereditary, which means that they run in families. Some kinds of cancer or certain cancers diagnosed in biological relatives may mean patients are more likely to have a genetic change. Once a genetic change is identified in a family, other biological relatives can choose to undergo testing themselves to better understand their cancer risk. The uptake of genetic testing in other biological relatives once a genetic condition is identified is about 20% to 30%. The Cascade Genetic Testing Platform is a virtual tool that seeks to overcome barriers related to logistics of family communication and improve dissemination of genetic testing information which is clinically actionable for individuals at highest risk for cancer. Using the Cascade Genetic Testing Platform may improve ways to share information about hereditary risk with biological relatives.
Eligibility
Inclusion Criteria10
- PROBANDS: Clinically confirmed autosomal dominant pathogenic germline variant (PGV) associated with a hereditary cancer syndrome
- PROBANDS: Previous evaluation by the University of Michigan (U-M) Cancer Genetics Clinic
- PROBANDS: ≥ 18 years old
- PROBANDS: Able to speak and read English
- PROBANDS: Access to the internet
- RELATIVES: Biological relative of proband
- RELATIVES: ≥ 18 years old
- RELATIVES: Able to speak and read English
- RELATIVES: Access to the internet
- RELATIVES: Have not completed germline genetic testing, per self-report at baseline
Exclusion Criteria1
- RELATIVES: Prior clinical germline genetic testing for cancer or already have an upcoming appointment scheduled with a genetics provider, per self-report at baseline
Interested in this trial?
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Interventions
Use relative invitation tool
Receive access to the VGN
Receive access to a Genetic Testing Family Letter
Ancillary studies
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06927947