RecruitingPhase 1NCT06931626

Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer

Study of NMS-03305293, a Non-Trapping PARP1-Specific PARP Inhibitor in Relapsed Small Cell Lung Cancer


Sponsor

Nerviano Medical Sciences

Enrollment

10 participants

Start Date

Aug 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open-label study of NMS-03305293 with Temozolomide (TMZ) in patients with Small Cell Lung Cancer (SCLC). The aim of this study is to determine the safety and tolerability, as well as to evaluate the anti-tumor efficacy and pharmacokinetics of NMS-03305293 in combination with TMZ.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new investigational drug called NMS-03305293 for people with extensive-stage small cell lung cancer (SCLC) that has relapsed — meaning the cancer came back after previous treatment including platinum-based chemotherapy and immunotherapy. **You may be eligible if...** - You are an adult (18 or older) - You have extensive-stage SCLC confirmed by a tissue sample - Your cancer returned within 6 months after first-line treatment with platinum-based chemotherapy plus immunotherapy - You have received no more than 3 prior lines of treatment - Your cancer is measurable on imaging - You are in adequate health (ECOG performance status of 2 or lower) - You are able to swallow capsules whole **You may NOT be eligible if...** - You are currently enrolled in another clinical trial - You have had brain metastases that are active or untreated - You have significant heart problems or other serious medical conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNMS-03305293

Route of administration: Oral

DRUGTemozolomide

Route of administration: Oral Commercially available Temozolomide


Locations(3)

OSF Saint Francis Medical Center

Peoria, Illinois, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Tennessee Oncology, PLLC

Nashville, Tennessee, United States

View Full Details on ClinicalTrials.gov

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NCT06931626


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