Subcortical Arousal in Perceptual Awareness
Shared Subcortical Arousal Systems Across Perceptual Modalities
Yale University
72 participants
Oct 13, 2025
INTERVENTIONAL
Conditions
Summary
The study is a multi-site study and will be conducted at up to 11 investigative sites in the United States. The study will investigate subcortical arousal circuits in visual perception using techniques with complementary strengths based on promising initial studies.
Eligibility
Inclusion Criteria3
- normal vision with or without the use of corrective lenses
- normal vision with or without the use of corrective lenses
- a female subject must have a negative pregnancy test and if sexually active, must be using a reliable form of birth control for the duration of the trial, be surgically sterile, or be at least two years post-menopausal.
Exclusion Criteria5
- severe vision impairment even with correction preventing ability to see stimuli (prevents accurate pupil and eye gaze measurements)
- unable to perform the perception task due to cognitive impairment. All participants must be capable of consenting for themselves.
- severe vision impairment even with correction preventing ability to see stimuli (prevents accurate pupil and eye gaze measurements)
- unable to perform the perception task due to cognitive impairment. All participants must be capable of consenting for themselves.
- pregnancy
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Interventions
Participants will have scalp EEG recorded with the international 10-20 system sampled at 256Hz using EEG amplifiers for purposes of surface event related potential analysis
An eye-tracking device may be used during the perceptual awareness task. Pupillary and gaze location measurements are recorded using either a ViewPoint\~VoltagePro.EyeLink 1000 Plus system, or Argus Science ETVision system. If using the ViewPoint\~VoltagePro system or the Argus Science ETVision system, participants will be asked to wear an eye tracker during the perceptual awareness task (similar to wearing sunglasses). If using the EyeLink 1000 Plus system, participants may be asked to place their head inside of a padded head-chin rest to stabilize head position
For the visual perceptual awareness task, the participant will be presented with barely perceptible visual stimuli. After a variable delay, the participant will be asked to report perception of each stimulus and identify its location.
Locations(8)
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NCT06934356