Metformin in Post Chronic Pancreatitis Diabetes Mellitus

Exclusion Criteria16

• Type 1 diabetes or secondary diabetes not caused by chronic pancreatitis (e.g. diabetes due to monogenic defects, cystic fibrosis, medications, autoimmune diseases, stress, or other factors).
• Contraindications or history of intolerance or allergy to metformin.
• Fasting C-peptide <0.3 nmol/L.
• Acute episodes of chronic pancreatitis at enrollment or within 3 months prior to enrollment.
• History of congestive heart failure (NYHA class 3 or greater), unstable angina, or other severe cardiovascular diseases.
• History of cancer (except non-melanoma skin cancer) within 5 years prior to screening.
• History of partial or total pancreatectomy.
• History of or planning bariatric surgery.
• Previous organ transplantation.
• Treatment with oral or systemic glucocorticoids within 3 months prior to enrollment or plan to use during the study (inhaled steroids are permitted).
• History of hemolytic anemia, chronic transfusion requirements, or other conditions rendering HbA1c results unreliable.
• Other conditions requiring glucose-lowering medications, such as polycystic ovary syndrome.
• Fasting blood glucose >11.1 mmol/L during screening, requiring immediate treatment as judged by the physician.
• Sever psychiatric disorders or health conditions deemed unsuitable for clinical research participation.
• Pregnancy or plans for pregnancy during the course of the study.
• Any other condition considered by the investigator to be inappropriate for participation in the trial.