RecruitingNot ApplicableNCT06937853

Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management

The Effect of Genetic Polymorphisms on the Response to Preoperative Non-Steroidal Anti-Inflammatory Drugs in the Management of Endodontic Postoperative Pain

Sponsor

Ataturk University

Enrollment

200 participants

Start Date

May 10, 2024

Study Type

INTERVENTIONAL

Conditions

Postoperative Pain

Summary

This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodontic treatment. Participants will receive standard preoperative NSAIDs before undergoing root canal therapy, and their pain responses will be assessed. Genetic analysis will be performed to investigate possible associations between drug response and individual gene variations. The study seeks to improve personalized approaches in endodontic pain management.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria5

Patients aged between 18 and 65 years
Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis
ASA physical status classification I or II
Preoperative VAS pain score greater than 50
No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain)

Exclusion Criteria12

Patients classified as ASA III or higher
Pregnant women or those suspected of being pregnant
Presence of root canal curvature greater than 25° (Schilder classification)
Patients with generalized periodontitis
Presence of periodontal pockets deeper than 3 mm in the affected tooth
History of systemic disease or known allergies
Patients with diagnosed psychiatric or psychological disorders
Presence of swelling, sinus tract, or preoperative tenderness on palpation
Patients with bruxism
Presence of resorption in the affected tooth
Use of analgesic or anti-inflammatory drugs within 12 hours prior to the procedure
Teeth with root fractures, ankylosis, or pathological mobility

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Interventions

DRUGIbuprofen 600 mg

A single oral dose of 600 mg ibuprofen will be administered prior to the endodontic procedure to evaluate its preemptive analgesic effect on postoperative dental pain.

DRUGdiclofenac sodium

A single oral dose of 100 mg diclofenac sodium will be administered to participants in the Diclofenac Sodium Group prior to the endodontic procedure. This intervention is designed to assess the preemptive analgesic efficacy of diclofenac sodium in the control of postoperative dental pain.

DRUGPlacebo

A single oral dose of a placebo tablet, identical in appearance to the active drugs, will be administered to participants in the Placebo Group prior to the endodontic procedure. This group serves as the control to evaluate the true analgesic efficacy of the active interventions.