Outcomes of Ablation of Unresectable Pancreatic Cancer Using the NanoKnife Irreversible Electroporation System-

This study is evaluating a procedure called irreversible electroporation (IRE), also known as NanoKnife, for treating locally advanced pancreatic cancer that cannot be removed by surgery. IRE uses electrical pulses to destroy tumor cells without damaging surrounding blood vessels or tissue. The study tracks outcomes in patients who have already received standard chemotherapy but whose cancer cannot be surgically removed. **You may be eligible if...** - You are 18 or older with locally advanced pancreatic cancer that cannot be removed surgically - You have already completed standard chemotherapy and possibly radiation - Your blood clotting levels are within safe range - You are willing to follow all study requirements **You may NOT be eligible if...** - Your kidney function is significantly impaired - You cannot stop blood-thinning medications before and after the procedure - You have a cardiac pacemaker or defibrillator - You have metal implants near the tumor area - You have a history of epilepsy or certain heart rhythm problems - You are pregnant or breastfeeding - You have a known allergy to contrast dye that cannot be managed medically Talk to your doctor to see if this trial is right for you.