Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)
Effects of Exercise Training on Health-related Quality of Life in Patients With Unresectable Metastatic Colorectal Cancer: A Multi-center Randomized Controlled Trial
Rigshospitalet, Denmark
150 participants
May 16, 2025
INTERVENTIONAL
Conditions
Summary
The primary objective of this trial is to compare the effects of 18 weeks structured exercise training versus on control on healt-related quality of life in patients with unresectable mCRC.
Eligibility
Inclusion Criteria1
- \- Adults (≥18 years of age) schduled to undergo chemotherapy for the treatment of unresectable metastatic colorectal cancer.
Exclusion Criteria6
- Pregnancy.
- A life expectancy of \< 6 months.
- Absolute contraindications to maximal exercise, as per the recommendations by the Danish Society of Cardiology.
- ECOG (Eastern Cooperative Oncology Group) performance status \> 2.
- Inability to understand the Danish or English language.
- Engagement in structured moderate-to-high aerobic exercise training for \>30 min \>1 times/week for the past 3 months at the time of inclusion.
Interventions
Participants allocated to the exercise intervention group will receive standard care plus an exercise intervention. The exercise intervention will consist moderate-to-high intensity supervised and unsupervised home-based exercise training (bicyling, walking, or running) 5 times/week for 18 weeks.
Locations(4)
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NCT06938971