Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)

This study is testing whether a supervised exercise program combining strength training and cardio can improve quality of life in people undergoing chemotherapy for metastatic colorectal cancer (cancer that has spread beyond the colon). Exercise is increasingly being studied as a way to reduce cancer treatment side effects and improve wellbeing. **You may be eligible if...** - You are 18 or older - You are scheduled to receive chemotherapy for unresectable metastatic colorectal cancer - You can understand Danish or English - You are in good enough general health to exercise **You may NOT be eligible if...** - You are pregnant - Your life expectancy is less than 6 months - You have heart conditions that make maximum exercise unsafe - Your performance status is too low to exercise - You have been doing structured moderate-to-high intensity aerobic exercise (30+ min, more than once a week) for the past 3 months Talk to your doctor to see if this trial is right for you.