Endocalyx in Treatment Resistent Hypertension

This study is testing whether a supplement called Endocalyx — which aims to support the lining of blood vessels — can help lower blood pressure in people with treatment-resistant hypertension. Treatment-resistant hypertension means blood pressure is still dangerously high despite taking three or more blood pressure medications at optimal doses. **You may be eligible if...** - Your blood pressure remains above 140/90 mmHg despite taking at least 3 different blood pressure medications, including a diuretic (water pill), at maximum tolerated doses - Your medications have been stable for the past 3 weeks - You have signed informed consent **You may NOT be eligible if...** - You are under 18 years old - Your kidney function is severely reduced (eGFR below 20) - Your blood pressure is extremely high (systolic above 180 or diastolic above 110) - You have a known secondary cause for your high blood pressure (e.g., a hormonal condition) - You have had a recent heart attack, stroke, or major surgery - You were recently hospitalized for heart failure - You are pregnant or not using adequate contraception Talk to your doctor to see if this trial is right for you.