Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged
Wound Healing Outcomes in Aged Extraction Patient With Platelet Rich Fibrinogen
University of Nebraska
12 participants
May 1, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.
Eligibility
Inclusion Criteria3
- Patient at University of Nebraska Medical Center (UNMC) College of Dentistry
- Requires extraction of posterior tooth
- Able and willing to provide consent/assent
Exclusion Criteria2
- Systemic conditions that delay wound healing
- Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy
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Interventions
Platelet-rich fibrin added to extraction socket
Locations(1)
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NCT06943846