RecruitingPhase 1NCT06945614

Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation

A Proof-of-Concept, Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation in Healthy Human Subjects

Sponsor

General Biophysics LLC

Enrollment

16 participants

Start Date

Apr 16, 2025

Study Type

INTERVENTIONAL

Conditions

Healthy Volunteer Study

Summary

The goal of this clinical study is to evaluate safety of Xenon gas inhalation in healthy volunteers. This first phase safety clinical study is part of evaluation of the xenon gas inhalation as a therapy for neurodegenerative diseases, such as Alzheimer's disease. The investigators will administer xenon gas in low concentration to people via anesthetic machine, observe participants for sedation and any unexpected side effects, collect blood at each visit and measure the vital signs. There are four treatment groups in the study, which correspond with the duration of xenon gas treatment. Individual participation will last approximately 14 days over five visits: screening visit accompanied by the electrocardiogram, blood, and urine test; treatment visit for xenon gas inhalation treatment; and three follow up visits.

Eligibility

Min Age: 55 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring whether inhaling small amounts of xenon gas — a colorless, odorless gas sometimes used in anesthesia — can safely reduce brain inflammation (neuroinflammation) in older adults. This type of inflammation is linked to conditions like dementia and Alzheimer's disease. **You may be eligible if...** - You are between 55 and 75 years old - You are in generally good health with no serious illnesses - Your heart rate, blood pressure, breathing rate, and blood oxygen levels are within normal ranges - You have no conditions that would interfere with the study measurements **You may NOT be eligible if...** - You have significant heart, lung, or neurological conditions - Your vital signs (blood pressure, heart rate, oxygen levels) fall outside acceptable ranges - You are on medications that could interact with xenon gas - You have conditions that make breathing studies unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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