Validation of a miRNA Panel to Optimize Treatment Response in Patients With Metastatic Pancreatic Cancer (mirPANC 2)

This study is collecting blood samples from patients with metastatic pancreatic cancer to see whether tiny molecules in the blood called microRNAs (miRNAs) can predict how well someone will respond to a specific chemotherapy regimen called FOLFIRINOX. The goal is to develop a blood test that guides treatment decisions. **You may be eligible if...** - You have been diagnosed with metastatic pancreatic cancer (cancer that has spread beyond the pancreas) - You are about to start chemotherapy with the FOLFIRINOX regimen - You are 18 years old or older - You are willing to provide informed consent **You may NOT be eligible if...** - You have previously received any chemotherapy for pancreatic cancer (including before or after surgery, or any prior first-line treatment) - Your health does not allow you to safely receive FOLFIRINOX (e.g., very high bilirubin levels, poor performance status, or advanced age making treatment too risky) Talk to your doctor to see if this trial is right for you.