HiSCs in the Treatment of Rheumatoid Arthritis

This study is testing a new cell therapy called HiSCs (a type of stem cell treatment) for people with rheumatoid arthritis (RA) whose knee joint symptoms have not improved enough with standard treatments. **You may be eligible if...** - You are between 18 and 65 years old - You have had a confirmed diagnosis of rheumatoid arthritis for at least 3 months - At the time of screening, you have at least one swollen and painful knee with inflammation confirmed by joint ultrasound - Your knee pain scores significantly on a standard pain scale (WOMAC score of 4 or higher) - Your symptoms have not improved adequately after 3 months of standard RA treatment **You may NOT be eligible if...** - Your RA is controlled by current treatment - You have other types of arthritis or joint conditions that could confuse the results - You have severe organ problems, active infections, or cancer - You are pregnant or breastfeeding - You have received certain prior treatments that could interfere with the study Talk to your doctor to see if this trial is right for you.