Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy
Brown University
60 participants
Apr 1, 2025
INTERVENTIONAL
Conditions
Summary
This project will investigate the effects of alternative nicotine products on smoking, weight gain, and related outcomes.
Eligibility
Inclusion Criteria6
- body mass index (BMI) ≥ 30 kg/m2 (i.e., obese)
- smoked ≥ 5 cigarettes/day during the past year
- or older (due to minimum legal age EC restrictions)
- exhaled breath carbon monoxide (CO) level > 6 ppm at Baseline (BL) (to confirm self-reported smoking)
- willing to use EC or NRT for 8 weeks
- access to a Bluetooth-enabled smartphone/tablet (to permit remote measurement of CO and other outcome variables)
Exclusion Criteria8
- received smoking cessation treatment of any kind in the past 30 days (actively quitting smoking),
- currently using EC or NRT more than 2 days/week (this may affect responses to study-supplied products)
- hospitalized for mental illness in past 30 days
- heart-related event (e.g., heart attack, severe angina) in past 30 days
- residing with another person currently enrolled in the study
- pregnant, nursing, or planning to become pregnant in the next 6 months
- medical contraindication for study or product use (e.g., allergy to adhesives)
- taken prescription weight loss medication in the last 30 days
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Interventions
Participants will receive information about the comparative risk of alternative nicotine products relative to smoking and will be asked to switch to EC for 8 weeks, with EC provided.
Participants will receive information about the comparative risk of alternative nicotine products relative to smoking and will be asked to switch to combination NRT (transdermal + oral) for 8 weeks, with NRT provided.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06948058