Acute Effects of THC in Older Adult
Yale University
60 participants
Jun 6, 2025
INTERVENTIONAL
Conditions
Summary
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Active Delta-9-THC administered intravenously over 20 minutes.
Small amount of sterile ethanol (1-2 mLs), with no THC, administered intravenously over 20 minutes.
Active Delta-9-THC administered intravenously over 20 minutes
Locations(1)
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NCT06948136