RecruitingNot ApplicableNCT06949774

INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)

INcentives and ReMINDers to Improve Long-term Medication Adherence

Sponsor

RAND

Enrollment

550 participants

Start Date

Apr 2, 2025

Study Type

INTERVENTIONAL

Conditions

Medication Adherence Habits HIV/AIDS

Summary

Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission. Routinized pill-taking can lead to successful long-term ART adherence, and short-term behavioral economics-based supports are a novel way to overcome the limited success of existing routinization interventions. This study proposes to test this combined approach for promoting long-term ART adherence using a Stage III Sequential, Multiple Assignment, Randomized Trial (SMART) design in one of the largest HIV clinics in Uganda to identify the most cost-effective adaptive intervention that if found effective is generalizable to other settings and other chronic diseases.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a combination of financial rewards (incentives) and text message reminders sent via mobile phone can help people living with HIV take their antiretroviral medications (ART) consistently over the long term. The study is conducted at Mildmay Uganda. **You may be eligible if...** - You are 18 years or older - You have started HIV treatment (ART) within the past 2 months at Mildmay or another clinic - You speak English or Luganda - You have your own phone or regular access to someone else's phone - You are willing to receive daily text messages for 6 months and use a special pill monitoring device (WisePill) **You may NOT be eligible if...** - You are not mentally fit to provide informed consent - You speak a language other than English or Luganda - You are not willing to use the WisePill adherence device consistently Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALDaily Text Messages

Participants will receive daily text message reminders to use their routine behavior to trigger medication adherence.

BEHAVIORALIncentivization based on timely ART adherence

Participants will be eligible to (draw a prize in monthly prize group) or get a monthly prize (monthly escalated group) if they take their medication within +/-one hour of the stated existing routine to which pill-taking is anchored on at least 80% of days for 3-months.