AI-Enhanced Optimization of Acute Levodopa Challenge Test

This study is using artificial intelligence to improve a test called the acute levodopa challenge test, which helps doctors figure out how well a person's Parkinson's disease (or similar condition) will respond to levodopa — a key medication for these disorders. Better optimization of this test could help personalize treatment. **You may be eligible if...** - You are between 50 and 75 years old - You have been diagnosed with Parkinson's disease, multiple system atrophy (MSA), progressive supranuclear palsy (PSP), or a related movement disorder - You are willing to undergo study-related evaluations and sign informed consent **You may NOT be eligible if...** - You do not have a confirmed diagnosis of one of the qualifying movement disorders - You are outside the 50–75 age range - You are unwilling or unable to consent to the study evaluations Talk to your doctor to see if this trial is right for you.