Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease
Ultrasound Perfusion Estimation for Assessment of PAD
Mayo Clinic
400 participants
Mar 14, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the response to interventional treatment in PAD patients.
Eligibility
Inclusion Criteria8
- Patient volunteers:
- Male and Female, ages 18 years old and up
- Symptom of claudication and suspected for PAD
- Scheduled for vascular testing.
- Healthy volunteers:
- Male and female, ages 18-75 years old and up
- Normal BMI
- No history of smoking, cardiovascular disease, or diabetes.
Exclusion Criteria11
- Patient volunteers:
- Patients with gangrene
- Patients having surgery or stent
- Patients with ulcer on their leg
- Any health condition that does not allow proper use of ultrasound scanning
- People considered in "vulnerable" populations.
- Healthy volunteers:
- Include volunteers with BMI not more than 30
- No history of smoking
- No history of (diabetes, hypertension, cardiovascular diseases)
- People considered in "vulnerable" populations.
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Interventions
Non-invasive ultrasound will be performed using Angio Flow Reactivity Analysis (AFRA) The ultrasound probe will be attached to the subject's calf muscle and a pressure cuff will be secured around thigh. Ultrasound data will be collected for 1 minute. The cuff will then be induced to a tolerable pressure of no more than 160 mm Hg, and ultrasound data will be collected for 3 minutes while cuff is inflated. The cuff pressure will be released, and ultrasound data will be collected for 2 minutes after the release. Subject will be asked to perform 1 minute plantar flexion exercise, and ultrasound data will be collected for two minutes after the completion of exercise
Locations(1)
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NCT06952543