A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks
Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks
Asian Institute of Gastroenterology, India
414 participants
Dec 20, 2025
INTERVENTIONAL
Conditions
Summary
Primary Objective • To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks among patients treated with Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg once daily. Secondary Objectives * To assess the improvement in reflux symptoms using the GERD-Q score at 8 weeks. * To evaluate the incidence of adverse events across treatment groups.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Vonaprazon is potassium competitive acid blockers
esomeprazole is a proton pump inhibitor as it prevents excess of gastric acid secretion in the stomach
Locations(1)
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NCT06953986