Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study

This study investigates whether a person's sense of smell (olfactory function) can help predict how long patients with glioblastoma — the most aggressive type of brain cancer — might survive and how they respond to treatment. Researchers will measure smell ability at diagnosis and track how it changes over time. **You may be eligible if...** - You are 18 or older with a newly diagnosed glioblastoma (a specific high-grade brain tumor type called IDH wild-type) - You have not received chemotherapy or radiation to the head or neck before - You have good enough functional ability (KPS score of 70 or above) - You do not have a respiratory infection at the time of enrollment **You may NOT be eligible if...** - You have a neurodegenerative disease (such as Parkinson's, Alzheimer's, or Huntington's disease) - You have had prior surgery or invasive procedures in the head or neck area for cancer - You have a permanent loss of smell caused by a previous infection (such as COVID-19 or influenza) - You have significant difficulty speaking or understanding language - Your participation would be limited by language barriers Talk to your doctor to see if this trial is right for you.