RecruitingNCT06955832

Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI

Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI: A Cross-sectional Study

Sponsor

Benha University

Enrollment

30 participants

Start Date

Jun 1, 2025

Study Type

OBSERVATIONAL

Conditions

Multiple Sclerosis

Summary

The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria. This study hypothesizes that: * PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p \< 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pathology.

Eligibility

Min Age: 15 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a specialized type of MRI scan called Phase Sensitive Inversion Recovery (PSIR) can detect brain lesions in people with multiple sclerosis (MS) earlier and more accurately than standard MRI sequences. Early detection of lesions can help guide treatment decisions. **You may be eligible if...** - You are between 15 and 65 years old (both male and female) - You have been diagnosed with multiple sclerosis according to established diagnostic criteria (McDonald Criteria) **You may NOT be eligible if...** - You are under 15 years old - You have had a stroke or prior bleeding in the brain - You have any contraindication to MRI (such as certain metal implants or a pacemaker) - Your condition is caused by something that mimics MS rather than being true MS Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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