Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI
Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI: A Cross-sectional Study
Benha University
30 participants
Jun 1, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria. This study hypothesizes that: * PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p \< 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pathology.
Eligibility
Inclusion Criteria3
- Age between 15-65 years.
- Both sexes.
- Patients with MS according to McDonald Criterion
Exclusion Criteria4
- Age less than 15 years old.
- Patients with stroke or previous intracranial hemorrhage.
- Contraindications to MRI scans.
- MS mimics.
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT06955832