RecruitingNCT06955832

Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI

Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI: A Cross-sectional Study


Sponsor

Benha University

Enrollment

30 participants

Start Date

Jun 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria. This study hypothesizes that: * PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p \< 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pathology.


Eligibility

Min Age: 15 YearsMax Age: 65 Years

Inclusion Criteria3

  • Age between 15-65 years.
  • Both sexes.
  • Patients with MS according to McDonald Criterion

Exclusion Criteria4

  • Age less than 15 years old.
  • Patients with stroke or previous intracranial hemorrhage.
  • Contraindications to MRI scans.
  • MS mimics.

Locations(3)

Banha University Hospitals

Banhā, Qalyubia Governorate, Egypt

El Mounira Multiple Sclerosis Unit

Cairo, Egypt

Naser Institute MS Unit

Cairo, Egypt

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06955832


Related Trials