RecruitingNCT06957626

Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy

Sponsor

Peking Union Medical College Hospital

Enrollment

150 participants

Start Date

Apr 25, 2023

Study Type

OBSERVATIONAL

Conditions

Colorectal Cancer Recurrent Colorectal Polyp Colorectal Adenoma

Summary

The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated. This study aims to analyze the microbial community characteristics in the intestinal mucosal tissue of patients after polypectomy with recurrence of colorectal polyps. Additionally, this research holds significant importance for understanding the etiology of adenoma recurrence and develop a microbiota and metabolite-based predicting tool.

Eligibility

Min Age: 40 YearsMax Age: 75 Years

Inclusion Criteria1

patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma

Exclusion Criteria7

patient with severe physical diseases that prevented them from adhering to the examination requirements,
patient with coagulopathy or other contraindications for biopsy or polypectomy,
patient with previous surgical procedures on the gastrointestinal tract,
presence of colorectal cancer or other malignant tumor at baseline
presence of inflammatory bowel disease or hereditary polyposis syndromes (such as family adenomatous polyposis or Lynch syndrome)
within 1 month before enrollment, oral antibiotics and probiotics were taken;
inability to provide informed consent or refusal to participate in the study.