Linezolid Plus Standard of Care

Exclusion Criteria13

• Administration of the initial drug treatment not feasible within 72 hours since the collection of the first positive blood culture with S. aureus
• Documented history of positive blood cultures for S. aureus occurring between 72 hours and 180 days prior to the eligibility assessment
• Necrotising fasciitis
• Currently receiving linezolid or clindamycin
• Use of any monoamine oxidase A or B inhibitor within the last two weeks
• Known hypersensitivity to linezolid or any other ingredients of the study drugs
• Current severe thrombocytopenia (i.e. \<30 x 10\^9/L)
• Application of study drug not possible (per mouth or per gastric tube)
• Currently breastfeeding
• Local treating team believes that death is imminent and inevitable
• Patient is receiving end of life care and antibiotic treatment is not considered appropriate
• Local treating team believes that participation in the study is not in the best interest of the patient
• Any indication that the patient is unwilling to participate in the study including an advance directive stating such unwillingness