RecruitingNot ApplicableNCT06958835

Linezolid Plus Standard of Care

Combination Antibiotic Treatment With Linezolid for Staphylococcus Aureus Bacteraemia: a Randomised Controlled Trial

Sponsor

University Hospital, Basel, Switzerland

Enrollment

606 participants

Start Date

Oct 6, 2025

Study Type

INTERVENTIONAL

Conditions

Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)

Summary

The aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with Staphylococcus aureus bacteraemia.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Linezolid 600 mg and a drug called Placebo for people with staphylococcus aureus bloodstream infections (bsi; bacteremia). The study is currently recruiting participants at 12 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLinezolid 600 mg

linezolid 600 mg tablets (twice a day for 5 days)

DRUGPlacebo

Placebo tablets (twice a day for 5 days)

Locations(12)

Kantonsspital Aarau (KSA)

Aarau, Canton of Aargau, Switzerland

St. Claraspital

Basel, Canton of Basel-City, Switzerland

Inselspital Bern

Bern, Canton of Bern, Switzerland

Hôpitaux universitaires de Genève (HUG)

Geneva, Canton of Geneva, Switzerland

Hôpital du Jura

Delémont, Canton of Jura, Switzerland

HOCH Health Ostschweiz, Kantonsspital St.Gallen

Sankt Gallen, Canton of St. Gallen, Switzerland

Centre hospitalier universitaire vaudois (CHUV)

Lausanne, Canton of Vaud, Switzerland

Kantonsspital Winterthur (KSW)

Winterthur, Canton of Zurich, Switzerland

Stadtspital Zürich Triemli

Zurich, Canton of Zurich, Switzerland

Universitätsspital Zürich (USZ)

Zurich, Canton of Zurich, Switzerland

Ente Ospedaliero Cantonale (EOC)

Lugano, Canton Ticino, Switzerland

University Hospital Basel (USB)

Basel, Switzerland

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NCT06958835

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