Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in Patients With Head and Neck Cancer

This study is testing a new drug called VS-101 added to the standard treatment (chemotherapy plus radiation) for locally advanced head and neck squamous cell carcinoma — cancers of the mouth, throat, voice box, or nearby areas. Researchers want to see if adding this drug makes standard treatment more effective. **You may be eligible if...** - You are 18 or older - You have been diagnosed with head and neck squamous cell carcinoma involving the oral cavity, oropharynx, hypopharynx, or larynx - Your cancer is locally advanced (stage III or IV) but has not spread to distant sites - You have not previously received chemoradiotherapy for this cancer - Your overall health is adequate for chemoradiotherapy **You may NOT be eligible if...** - Your cancer has spread to distant organs (metastatic) - You have had prior radiation to the head and neck region - You have significant kidney, liver, or blood count abnormalities - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.