RecruitingNot ApplicableNCT06960902

Study of the Determinants of Coronary Atherosclerosis in Familial Hypercholesterolemia (ATHERO-FH Study)

Study of the Determinants of Coronary Atherosclerosis in Familial Hypercholesterolemia


Sponsor

Nantes University Hospital

Enrollment

600 participants

Start Date

Sep 25, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study (interventional clinical research not involving a health product) is to assess the prevalence of subclinical coronary atherosclerosis diagnosed by coronary CT angiography in heart failure patients in primary prevention, across different levels of cardiovascular risk defined by coronary artery calcium (CAC) score percentiles (based on data from the MESA study): low risk (≤25th percentile for age, sex, and ethnicity), intermediate risk (25th \< CAC ≤ 75th percentile), and high risk (\>75th percentile). The Patients will attend an on-site visit at inclusion (and must undergo a coronary CT angiography within 6 months following this visit), will be contacted by phone at 1 year and 2 years, and will return for an on-site visit at 30 months.


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Coronary CT scan with CAC score measurement for people with atherosclerotic cardiovascular disease (ascvd) and familial hypercholesterolemias. The study is currently recruiting participants at 9 locations. People eligible for this study include aged 40 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCoronary CT scan with CAC score measurement

Coronary CT scan with CAC score measurement (on the same day or within 6 months after the inclusion visit).


Locations(9)

CHU Dijon Bourgogne

Dijon, France

CHRU Lille

Lille, France

Hospices Civils de Lyon

Lyon, France

Hôpital de la Conception, AP-HM

Marseille, France

CHU Nantes

Nantes, France

Hôpital de la Pitié-Salpêtrière, AP-HP

Paris, France

Hôpital Saint-Antoine, AP-HP

Paris, France

CHU Rennes

Rennes, France

CHU Strasbourg

Strasbourg, France

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NCT06960902


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