RecruitingNot ApplicableNCT06961929

IEEM-Heat and Heart Failure


Sponsor

University of Texas Southwestern Medical Center

Enrollment

88 participants

Start Date

Oct 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

We will test the hypothesis that increasing skin wetness, and thus evaporative cooling, will attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. Secondly, we propose that wearing a water-saturated T-shirt will also be beneficial to attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. To accomplish these objectives, individuals with congestive heart failure and otherwise healthy control individuals will be exposed to the simulated heat wave condition (hot and dry) with the following cooling modalities: A) control trial (no limb immersion or skin wetting), B) skin wetting only trial, and C) water-saturated T-shirt trial in a randomized crossover fashion. Thermoregulatory and cardiovascular responses will be evaluated throughout these simulated heat wave exposures. Primary outcomes variables will be skin and core temperatures, while secondary variables will include measures of cardiovascular stress, myocardial perfusion, heart rate, and echo-based measures of cardiac function.


Eligibility

Min Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how heat exposure affects the heart and body in two groups: healthy people and people with congestive heart failure (CHF). The goal is to understand whether heat causes different stress responses in people with heart failure, which could have implications for patient care during hot weather. **You may be eligible if (healthy volunteers)...** - You are 45 or older - You have no significant underlying medical conditions - You are a non-smoker (and have not smoked regularly in the past 12 months) **You may be eligible if (heart failure group)...** - You are 45 or older - You have a confirmed diagnosis of congestive heart failure at NYHA class II or III severity **You may NOT be eligible if...** - You have cancer, diabetes, neurological disease, uncontrolled hypertension, or lung disease - You are a current or recent smoker - You are on blood thinners (anticoagulants) - You have severe valve disease, NYHA Class IV heart failure, or significant coronary artery disease - You have a left bundle branch block on your ECG Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERControl Trial

All participants will be exposed to a period of hyperthermia (hot and dry). In this condition, participants will not be given an experimental cooling modality.

OTHERWater-saturated T-shirt trial

All participants will be exposed to a period of hyperthermia (hot and dry). In this condition, participants will also wear a T-shirt that has been saturated with water.

OTHERSkin-Wetting Trial

All participants will be exposed to a period of hyperthermia (hot and dry). In this condition, participants will also be sprayed with water periodically.


Locations(1)

Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas

Dallas, Texas, United States

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NCT06961929


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