RecruitingNot ApplicableNCT06962527

Test of Target Engagement of Ambiguity Aversion

Computational Modeling of Ambiguity Aversion in Internalizing Disorders: Neural and Behavioral Markers, and a Test of Target Engagement


Sponsor

Northwestern University

Enrollment

140 participants

Start Date

Jul 7, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.


Eligibility

Min Age: 25 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how the brain processes uncertainty and ambiguity — and how that relates to decision-making and anxiety. Participants will undergo brain scans (MRI) and complete tasks designed to measure how they respond to uncertain situations. This research aims to improve our understanding of mental health conditions linked to intolerance of uncertainty. **You may be eligible if...** - You are between 25 and 60 years old - You are right-handed - You can read and write in English - You score in the higher range on a questionnaire measuring discomfort with uncertainty (31st percentile or above) **You may NOT be eligible if...** - You have a personal history of psychosis, mania, or hypomania - You have been diagnosed with autism spectrum disorder - Your IQ is below 80 - You have had a significant head injury with loss of consciousness over 2 minutes - You have a neurological condition (such as epilepsy, Parkinson's disease, or history of stroke) - You are currently pregnant - You have an implanted electrical device (like a pacemaker or spinal stimulator) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALUncertainty-focused single session intervention

Digitally/computer administered 30-minute self-guided intervention for adults ages 25-60

BEHAVIORALMaintaining a healthy lifestyle single session intervention

Digitally/computer administered 30-minute self-guided intervention for adults ages 25-60


Locations(1)

Northwestern University

Chicago, Illinois, United States

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NCT06962527


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