RecruitingNot ApplicableNCT06962527

Test of Target Engagement of Ambiguity Aversion

Computational Modeling of Ambiguity Aversion in Internalizing Disorders: Neural and Behavioral Markers, and a Test of Target Engagement

Sponsor

Northwestern University

Enrollment

140 participants

Start Date

Jul 7, 2025

Study Type

INTERVENTIONAL

Conditions

Depression, Anxiety Anxiety Intolerance of Uncertainty Intolerance of Uncertainty; Anxiety

Summary

The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.

Eligibility

Min Age: 25 YearsMax Age: 60 Years

Inclusion Criteria5

Ages 25 to 60
Right-handed
Ability to read and write English
Capacity to provide informed consent
Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)

Exclusion Criteria7

Personal history of psychosis, mania, or hypomania
Personal history of autism spectrum disorder
IQ \< 80 as determined by the Wechsler Test of Adult Reading
Head injury with greater than 120 seconds loss of consciousness
Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)
Currently pregnant
Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).