Depression, Anxiety Clinical Trials

63 recruitingLast updated: June 17, 2026

There are 63 actively recruiting depression, anxiety clinical trials across 23 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 4. Top locations include Boston, Massachusetts, United States, Aurora, Colorado, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Depression, Anxiety Trials at a Glance

63 actively recruiting trials for depression, anxiety are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Not Applicable with 43 trials, with the heaviest enrollment activity in Boston, Aurora, and New York. Lead sponsors running depression, anxiety studies include Massachusetts General Hospital, University of Colorado, Denver, and Ottawa Hospital Research Institute.

Browse depression, anxiety trials by phase

Treatments under study

About Depression, Anxiety Clinical Trials

Looking for clinical trials for Depression, Anxiety? There are currently 62 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Depression, Anxiety trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Depression, Anxiety clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 63 trials

Recruiting
Not Applicable

Training in Evidence-based Treatments in Psycho-Oncology

PainDepression, AnxietyDistress, Emotional+2 more
Massachusetts General Hospital115 enrolled1 locationNCT05674357
Recruiting
Not Applicable

Cognitive Behavior Therapy in Psychiatric Inpatient Care

Depression, Anxiety DisordersPsychiatric Inpatients
Region Stockholm204 enrolled1 locationNCT07503951
Recruiting
Not Applicable

Test of Target Engagement of Ambiguity Aversion

Depression, AnxietyAnxietyIntolerance of Uncertainty+1 more
Northwestern University140 enrolled1 locationNCT06962527
Recruiting
Not Applicable

Harlem Strong Mental Health Coalition

Depression, AnxietyStress-related ProblemMental Health Wellness
City University of New York, School of Public Health700 enrolled2 locationsNCT05833555
Recruiting
Not Applicable

The COMParing App Support Strategies Study

Depression, Anxiety
University of Wisconsin, Madison688 enrolled1 locationNCT07278466
Recruiting
Not Applicable

Youth Emotional and Behavioral Treatment Study

Depression, Anxiety
Florida State University500 enrolled1 locationNCT07296939
Recruiting
Not Applicable

Prevention of Psychological Health Problems Via Integrated Operational Support

Depression, AnxietyGriefLeadership+1 more
New York University5,586 enrolled1 locationNCT06981598
Recruiting
Phase 2

Modulating Exercise Dosage to Improve Concussion Recovery

TreatmentDepression, AnxietyAerobic Exercise+2 more
University of Colorado, Denver216 enrolled3 locationsNCT05434130
Recruiting
Not Applicable

Examining the Efficacy of a Digital Therapeutic to Prevent Suicidal Behaviors

Depression, AnxietySuicidal BehaviorsSuicide Ideation
University of Memphis400 enrolled1 locationNCT06318962
Recruiting
Not Applicable

Multidimensional Sleep Health Intervention to Optimize Concussion Recovery

TreatmentDepression, AnxietySleep Health+2 more
University of Colorado, Denver54 enrolled1 locationNCT07082218
Recruiting
Phase 1Phase 2

Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

Quality of LifeDepression, AnxietyStress Reaction+1 more
Children's Hospital Los Angeles66 enrolled1 locationNCT05685368
Recruiting
Not Applicable

Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain

Depression, AnxietyChronic Pain
Washington University School of Medicine1,000 enrolled1 locationNCT06978166
Recruiting
Not Applicable

Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons

Depression, AnxietyDepressionAnxiety+1 more
University of Wisconsin, Madison96 enrolled1 locationNCT06162624
Recruiting
Not Applicable

Weekly Dynamics of Psychopathological and Symptom Networks During Mindfulness-Based Interventions for Emotional Distress

Depression, AnxietyEmotional Disorders
Peking University500 enrolled1 locationNCT07280481
Recruiting
Not Applicable

Promoting Mental Health of Teachers and Caregiver Using a Personalized mHealth Toolkit in Uganda

Depression, AnxietyMental Health Literacy
NYU Langone Health1,180 enrolled2 locationsNCT06087159
Recruiting
Phase 2

Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

Advanced CancerDepression, AnxietyPsilocybin-Assisted Psychotherapy
M.D. Anderson Cancer Center30 enrolled1 locationNCT06200155
Recruiting
Not Applicable

Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in Zimbabwe

Depression, AnxietyHIV InfectionsPregnancy Related
Massachusetts General Hospital132 enrolled1 locationNCT06226155
Recruiting

Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.

Depression, AnxietySurvivors of Childhood CancerGeneralized Anxiety+1 more
Centre Hospitalier Universitaire de Saint Etienne545 enrolled7 locationsNCT07117058
Recruiting
Not Applicable

intErnet-based iNterventions FOR Cardiac arrEst suRvivors

Quality of LifeSexual DysfunctionDepression, Anxiety+3 more
Azienda Usl di Bologna106 enrolled2 locationsNCT06395558
Recruiting
Not Applicable

Technology-assisted Methods to Advance Suicide Prevention Among Youth in Colombia

Depression, AnxietyWell-beingSuicidal Ideations+1 more
Brown University228 enrolled1 locationNCT06651554