RecruitingNot ApplicableNCT06971549

Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS

Sponsor

The Hong Kong Polytechnic University

Enrollment

1 participants

Start Date

Mar 19, 2025

Study Type

INTERVENTIONAL

Conditions

Depression

Summary

This study will investigate the cortical hemodynamic response variability of an accelerated form of TBS stimulation over left dorsolateral prefrontal cortex (DLPFC) using a concurrent TBS/fNIRS setup. The accelerating TMS protocol that will be used in this study is similar to the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), i.e., fifty iTBS sessions (1,800 pulses per session, 50-minute intersession interval) will be delivered as 10 daily sessions over 5 consecutive days at 90% resting motor threshold. The investigators will recruit a depressed patient and conduct a concurrent iTBS/fNIRS protocol for each iTBS session. Moreover, the depression symptoms of the patient will be assessed before and after treatment.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria6

aged 18 to 65;
a clinical diagnosis of current nonpsychotic major depressive disorder by an experienced psychiatrist according to DSM-IV;
no or stable (≥2 weeks) psychopharmacological medication;
have not responded to at least one antidepressant medication;
have not received any TMS treatment;
and have a 17-item HAMD score ≥ 20.

Exclusion Criteria5

severe internal diseases;
neurological disorders or a history of severe head injuries;
having suicidal ideation;
pregnancy;
antiepileptics and benzodiazepines corresponding to a dose of \>1 mg lorazepam/d.

Interventions

OTHERAccelerated iTBS

Fifty iTBS sessions (1,800 pulses per session, 50-minute intersession interval) will be delivered as 10 daily sessions over 5 consecutive days at 90% resting motor threshold.