RecruitingNot ApplicableNCT06971549

Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS

Sponsor

The Hong Kong Polytechnic University

Enrollment

1 participants

Start Date

Mar 19, 2025

Study Type

INTERVENTIONAL

Conditions

Depression

Summary

This study will investigate the cortical hemodynamic response variability of an accelerated form of TBS stimulation over left dorsolateral prefrontal cortex (DLPFC) using a concurrent TBS/fNIRS setup. The accelerating TMS protocol that will be used in this study is similar to the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), i.e., fifty iTBS sessions (1,800 pulses per session, 50-minute intersession interval) will be delivered as 10 daily sessions over 5 consecutive days at 90% resting motor threshold. The investigators will recruit a depressed patient and conduct a concurrent iTBS/fNIRS protocol for each iTBS session. Moreover, the depression symptoms of the patient will be assessed before and after treatment.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a brain stimulation technique called iTBS (intermittent theta burst stimulation) as a treatment for depression, while also tracking blood flow in the brain using a light-based sensor worn on the head. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with major depressive disorder (non-psychotic) by a psychiatrist - You have tried at least one antidepressant medication but it did not work well enough - Your medications have been stable for at least 2 weeks (or you are not on any) - You have never had TMS (brain stimulation) treatment before - Your depression score on a standard rating scale is 20 or higher **You may NOT be eligible if...** - You have serious internal organ diseases or neurological disorders - You have a history of severe head injuries, brain surgery, or seizures - You have a pacemaker, deep brain stimulator, or metal in your head - You currently have suicidal thoughts - You are pregnant - You take high doses of anti-seizure or benzodiazepine medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERAccelerated iTBS

Fifty iTBS sessions (1,800 pulses per session, 50-minute intersession interval) will be delivered as 10 daily sessions over 5 consecutive days at 90% resting motor threshold.