Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The APT Comparison Study
Mayo Clinic
1,335 participants
Jul 9, 2025
INTERVENTIONAL
Conditions
Summary
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Atogepant at a dose up to 60 mg daily.
Daily propranolol up to 80 mg twice daily.
Daily topiramate, up to 50 mg twice daily
Locations(35)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06972056