Home-Based tDCS Treatment Of Major Depressive Disorder

This study is testing a home-based brain stimulation treatment called tDCS (transcranial direct current stimulation) for people with major depression. The device delivers a very mild electrical current to the scalp using a headset and is used at home, while the study team monitors your progress remotely. **You may be eligible if...** - You are between 22 and 70 years old - You have been diagnosed with major depressive disorder (MDD) - Your depression symptoms are moderate to severe (PHQ-9 score at least 13, MADRS at least 20) - You are currently taking antidepressant medication - You have access to a smartphone (Android 7.0+ or iPhone iOS 13+) - You are under the care of a psychiatrist or primary care doctor - You can read and communicate in English **You may NOT be eligible if...** - You have a history of mania or psychosis - Your depression has not responded to multiple treatments (treatment-resistant depression) - You have ever attempted suicide or have moderate-to-high suicide risk - You have a metal implant in your head or brain, or a pacemaker - You have a history of epilepsy or seizures - You have previously had brain stimulation treatments (ECT, TMS, DBS, or tDCS) - You have untreated sleep apnea or insomnia unrelated to depression Talk to your doctor to see if this trial is right for you.