RecruitingNCT06978985

Adult SMA Research and Clinical Hub

Adult SMA REACH: Development and Implementation of a Standardised Data Set and Data Collection Research Study in the UK Adult SMA Population

Sponsor

Newcastle-upon-Tyne Hospitals NHS Trust

Enrollment

600 participants

Start Date

Jul 29, 2022

Study Type

OBSERVATIONAL

Conditions

Spinal Muscular Atrophy (SMA)

Summary

Adult SMA REACH is a data collection study aiming to gain a better understanding of the impact of standards of care and new treatments on the natural history of Spinal Muscular Atrophy (SMA). This study is sponsored by The Newcastle upon Tyne Hospitals NHS Foundation Trust. Adult SMA REACH is funded by Biogen and Roche. Currently, there are three drug treatments available for SMA in the UK: Zolgensma, Nusinersen and Risdiplam. Zolgensma is the only approved drug - Nusinersen and Risdiplam are currently available as part of Managed Access Agreements (MAA).

Eligibility

Min Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Nusinersen Injectable Product and a drug called Risdiplam for people with spinal muscular atrophy (sma). The study is currently recruiting participants at 18 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGRisdiplam

Risdiplam

DRUGNusinersen Injectable Product

Nusinersen

Locations(18)

University Hospitals Birmingham NHS Foundation Trust

Birmingham, United Kingdom

North Bristol NHS Trust

Bristol, United Kingdom

Cambridge University Hospitals NHS Foundation Trust

Cambridge, United Kingdom

Cardiff and Vale University Health Board

Cardiff, United Kingdom

NHS Greater Glasgow and Clyde

Glasgow, United Kingdom

Bradford Teaching Hospitals NHS Foundation Trust

Leeds, United Kingdom

The Walton Centre NHS Foundation Trust

Liverpool, United Kingdom

University College London Hospitals NHS Foundation Trust

London, United Kingdom

King's College Hospital NHS Foundation Trust

London, United Kingdom

St George's University NHS Foundation Trust

London, United Kingdom

Newcastle-upon-Tyne Hospitals NHS Trust

Newcastle upon Tyne, United Kingdom

Nottingham University Hospitals Trust

Nottingham, United Kingdom

The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust

Oswestry, United Kingdom

Oxford University Hospitals Trust

Oxford, United Kingdom

The Northern Care Alliance NHS Foundation Trust

Salford, United Kingdom

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, United Kingdom

University Hospital Southampton NHS Foundation Trust

Southampton, United Kingdom

South West Wales Neuromuscular Service in Swansea

Swansea, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06978985

Related Trials

VRehab-SMA Phase 1.2

NCT075784541 location

A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy

NCT0728798217 locations

Assessment of a Portable Digital Device for Quantified Analysis of Markerless Walking in Volunteers With Neuromuscular Diseases or Asymptomatic Volunteers

NCT073219771 location

An International Federated Model for Wearable-derived Remote Longitudinal Motor Monitoring in Young Children With Spinal Muscular Atrophy Compared With Healthy Controls: Active-NBS Study (UK)

NCT075430031 location

HABIT-ILE + FST in Children With SMA: Preliminary Effectiveness

NCT074883381 location